Thermo-immune synergy: Camrelizumab plus microwave ablation in preoperative early-stage breast cancer

Immunotherapy has enhanced breast cancer outcomes, but optimizing combination therapies is crucial. Integrating additional treatment modalities, like physical therapies, holds promise for optimizing efficacy. Pan et al. recently reported that combining preoperative immunotherapy with microwave ablation is safe and feasible in early-stage breast cancer, effectively sensitizing peripheral CD8+ T cells. 1 Pan H. Yu M. Tang X. Mao X. Liu M. Zhang K. Qian C. Wang J. Xie H. Qiu W. et al. Preoperative single-dose camrelizumab and/or microwave ablation in women with early-stage breast cancer: A randomized window-of-opportunity trial. Med. 2024; https://doi.org/10.1016/j.medj.2024.01.015 Abstract Full Text Full Text PDF Scopus (1) Google Scholar Immunotherapy has enhanced breast cancer outcomes, but optimizing combination therapies is crucial. Integrating additional treatment modalities, like physical therapies, holds promise for optimizing efficacy. Pan et al. recently reported that combining preoperative immunotherapy with microwave ablation is safe and feasible in early-stage breast cancer, effectively sensitizing peripheral CD8+ T cells. 1 Pan H. Yu M. Tang X. Mao X. Liu M. Zhang K. Qian C. Wang J. Xie H. Qiu W. et al. Preoperative single-dose camrelizumab and/or microwave ablation in women with early-stage breast cancer: A randomized window-of-opportunity trial. Med. 2024; https://doi.org/10.1016/j.medj.2024.01.015 Abstract Full Text Full Text PDF Scopus (1) Google Scholar Preoperative single-dose camrelizumab and/or microwave ablation in women with early-stage breast cancer: A window-of-opportunity trialPan et al.MedFebruary 27, 2024In BriefInnovative treatments are still needed to reduce metastatic disease for early-stage breast cancer. Pan et al. found that local microwave ablation combined with camrelizumab showed a favorable local effect and systemic immune response in the treatment of early-stage breast cancer, and the long-term effect of this strategy is worth investigating. Full-Text PDF