乙酰化
组蛋白
癌变
抑制因子
癌症研究
化学
细胞生物学
生物化学
生物
转录因子
基因
作者
Shixun Han,Haonan Fan,Guoxuan Zhong,Lei Ni,Wenhao Shi,Yushan Fang,Chenliang Wang,Li Wang,Lang Song,Jianhui Zhao,Mei Tang,Bing Yang,Li Li,Xueli Bai,Qi Zhang,Tingbo Liang,Yanhui Xu,Xin‐Hua Feng,Chen Ding,Dong Fang
出处
期刊：Hepatology
[Lippincott Williams & Wilkins]
日期：2024-04-01
卷期号：81 (3): 808-822
被引量：13
标识
DOI：10.1097/hep.0000000000000875
摘要
Our data show that nuclear KRT19 acts as a transcriptional corepressor through promoting the deacetylase activity of the CoREST complex, resulting in dedifferentiation of liver cancer. These findings reveal a previously unrecognized function of KRT19 in directly shaping the epigenetic landscape in cancer.
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