内大麻素系统
背景(考古学)
大麻素受体
大麻
医学
药理学
大麻素
受体
生物
内科学
兴奋剂
精神科
古生物学
作者
Tiffany Y.-C. Tang,Justin S. Kim,Aditi Das
出处
期刊:Advances in pharmacology
日期:2023-01-01
卷期号:: 375-422
标识
DOI:10.1016/bs.apha.2023.02.003
摘要
Endocannabinoids are derived from dietary omega-3 and omega-6 fatty acids and play an important role in regulation of inflammation, development, neurodegenerative diseases, cancer, and cardiovascular diseases. They elicit this effect via interactions with cannabinoid receptors 1 and 2 which are also targeted by plant derived cannabinoid from cannabis. The evidence of the involvement of the endocannabinoid system in cardiopulmonary function comes from studies that show that cannabis consumption leads to cardiovascular effect such as arrythmia and is beneficial in lung cancer patients. Moreover, omega-3 and omega-6 endocannabinoids play several important roles in cardiopulmonary system such as causing airway relaxation, suppressing atherosclerosis and hypertension. These effects are mediated via the cannabinoids receptors that are abundant in the cardiopulmonary system. Overall, this chapter reviews the known role of phytocannabinoids and endocannabinoids in the cardiopulmonary context.
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