内科学
内分泌学
肠道菌群
胰高血糖素样肽-1
脂肪组织
产热
胰岛素抵抗
生物
肥胖
G蛋白偶联胆汁酸受体
褐色脂肪组织
胆汁酸
2型糖尿病
医学
糖尿病
生物化学
作者
Chunxiu Chen,Lingli Liu,Ying Zhong,Miaoran Wang,Yanbiao Ai,Yi Hou,Hong Chen,Xiaojing Lin,Yunqi Zhang,Min Ding,Ting Luo,Jibin Li,Xinyu Li,Xiaoqiu Xiao
标识
DOI:10.1016/j.jnutbio.2023.109358
摘要
In human and rodents, some individuals may remain lean even when they are challenged with high calorie intake. Here, we used C57BL/6J mice to establish animal models of high-fat diet (HFD) induced obesity sensitive (DIO) mice and obesity resistant (DIR) mice. In DIR mice, improved metabolic profile through brown adipose tissue (BAT) activation was observed, while plasma unconjugated bile acids (BAs) were decreased together with increased intestine tauro-conjugated BAs (e.g., T-β-MCA). The composition of the gut flora also differs greatly between DIR and DOR. Using fecal microbiota transplants from DIR mice, HFD fed recipient mice exhibited a trend toward reduced adiposity and improved glucose tolerance, showing increased serum tauro-conjugated BAs levels. STC-1 cell experiments confirmed T-β-MCA could activate FXR/TGR5 pathway and induce the production of GLP-1, inhibiting genes that regulate the ceramide synthesis. Our results indicated that the DIR mice exhibited higher energy expenditure by activating BAT thermogenesis, which may be related to altered gut microbiota-bile acids-glucagon like peptide-1 axis.
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