医学
减肥
哮喘
心理干预
背景(考古学)
肥胖
重症监护医学
人口
体重管理
共病
物理疗法
环境卫生
内科学
精神科
古生物学
生物
作者
Dinah Foer,Erick Forno,Fernando Holguín,Katherine N. Cahill
标识
DOI:10.1016/j.jaip.2023.12.041
摘要
ABSTRACT
Obesity is a common asthma comorbidity in adults, contributing to higher patient morbidity and mortality. Conversely, weight loss can reduce the impact of obesity on asthma and improve patient outcomes by diverse mechanisms including modulating airway inflammation, reducing oxidative stress, and improving lung function. Multiple lifestyle, non-pharmacological, pharmacological, and surgical interventions are effective at reducing weight in the general population. Fewer have been studied specifically in the context of patients with asthma. However, increasingly effective pharmacologic options for weight loss highlight the need for allergists and pulmonologists to understand the range of approaches that may directly or indirectly yield clinical benefits in asthma management. Weight loss interventions often require multi-disciplinary support to create strategies that can realistically achieve a patient's personalized asthma and weight goals. This includes minimizing the adverse weight effects of glucocorticoids which remain a mainstay of asthma management. Disparities in access, cost and insurance coverage of weight loss interventions remain acute challenges for providers and patients. Future studies are needed to elucidate mechanisms of action of specific weight loss interventions on short-term and long-term asthma outcomes.
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