髓系白血病
造血
髓样
生殖系
暴发型
白血病
疾病
癌症研究
免疫学
生物
干细胞
医学
内科学
遗传学
基因
作者
Franziska Wachter,Yana Pikman
出处
期刊:Acta Haematologica
[S. Karger AG]
日期:2024-01-16
摘要
Acute myeloid leukemia (AML) is a biologically heterogenous disease arising in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads to expanded proliferation of clonal myeloid progenitors and failure of differentiation, leading to fulminant AML. Here we review the pathophysiology of AML with a focus on factors predisposing to AML development, including prior chemo- and radiation therapy, environmental factors, and germline predisposition. Increasing genomic characterization of AML and insight into mechanisms of its development will be critical to improvement in AML prognostication and therapy.
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