催化作用
分子内力
化学
药物化学
立体化学
有机化学
作者
Hugo Esteves,Tania Xavier,Sonia Lajnef,Fabienne Peyrot,Guillaume Lefèvre,Guillaume Prestat,Farouk Berhal
标识
DOI:10.1021/acscatal.3c04900
摘要
An iron-catalyzed lactonization reaction via intramolecular C(sp3)-H functionalization is described. The process employs easily accessible hydroxamate derivatives from which the noncommon insertion of the oxygen occurred through a 1,5-hydrogen atom transfer. A mixture of water and hexafluoroisopropanol as solvent appeared to be the key parameter of this transformation to reach a high selectivity and efficiency.
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