再生(生物学)
组织工程
自愈水凝胶
乙二醇
制作
3d打印
明胶
材料科学
3D打印
快速成型
生物医学工程
纳米技术
工程类
化学
细胞生物学
复合材料
生物
高分子化学
医学
生物化学
替代医学
有机化学
病理
作者
Huimin Fang,Jihui Ju,Lifeng Chen,Muran Zhou,Zhang Guo,Jinfei Hou,Wenbin Jiang,Zhenxing Wang,Jiaming Sun
标识
DOI:10.1002/advs.202308381
摘要
Abstract 3D bioprinting techniques have enabled the fabrication of irregular large‐sized tissue engineering scaffolds. However, complicated customized designs increase the medical burden. Meanwhile, the integrated printing process hinders the cellular uniform distribution and local angiogenesis. A novel approach is introduced to the construction of sizable tissue engineering grafts by employing hydrogel 3D printing for modular bioadhesion assembly, and a poly (ethylene glycol) diacrylate (PEGDA)‐gelatin‐dopamine (PGD) hydrogel, photosensitive and adhesive, enabling fine microcage module fabrication via DLP 3D printing is developed. The PGD hydrogel printed micocages are flexible, allowing various shapes and cell/tissue fillings for repairing diverse irregular tissue defects. In vivo experiments demonstrate robust vascularization and superior graft survival in nude mice. This assembly strategy based on scalable 3D printed hydrogel microcage module could simplify the construction of tissue with large volume and complex components, offering promise for diverse large tissue defect repairs.
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