光热治疗
紧身衣
化学
纳米颗粒
组合化学
光化学
纳米技术
材料科学
荧光
物理
量子力学
作者
Linfeng Cao,Yikun Li,Dongxiang Zhang,Shuai Yue,Rong Shang,Xin‐Dong Jiang,Jianjun Du
标识
DOI:10.1016/j.cclet.2024.109735
摘要
Near infrared-II (NIR-II) dyes have unique advantages in biomedical applications owing to the powerful ability in penetrating biological tissues. Herein, NIR-II aza-BODIPY dye, QLD-BDP, was developed with julolidine at 1,7-sites and p-dimethylaminophenyl group at 3,5-sites. According to X-ray analysis, QLD-BDP exhibits significant distortion, and this molecule appears a bowl shaped structure. The photothermal conversion efficiency of the self-assembled QLD-BDP nanoparticles (QLD-BDP-NPs) can reach 50.5%, with maximum emission at 998 nm by the aggregate. QLD-BDP-NPs can cause the complete destruction of 4T1 multicellular spheroids (MCSs), indicating a photothermal therapy (PTT) effect.
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