贝伐单抗
药物输送
淋巴系统
脑膜
单线态氧
医学
脑癌
脑瘤
药理学
化疗
病理
癌症
化学
内科学
纳米技术
材料科学
氧气
有机化学
作者
Oxana Semyachkina-Glushkovskaya,Sergey Diduk,Eroshova Anna,Dosadina Elina,Kruglov Artem,Alexander Khorovodov,Alexander Shirokov,Ivan V. Fedosov,Alexander Dubrovsky,Inna Blokhina,Andrey Terskov,Georgy Karandin,Arina Evsukova,Anna Tsven,Valeria Telnova,Ilana Afranovich,Sergey Sokolovski,Э.У. Рафаилов,Jürgen Kurths
标识
DOI:10.1007/978-3-031-14190-4_9
摘要
The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. Therefore, the development of safe methods for an effective delivery of medications to the brain can be a revolutionary step in overcoming this limitation. Using a quantum-dot-based 1267 nm laser (photosensitiser-free generation of singlet oxygen), we clearly show the photostimulation of lymphatic delivery of bevacizumab (BMZ) to the brain tissues and the meninges. These pilot findings open promising perspectives for photomodulation of a lymphatic brain drug delivery bypassing the BBB, and potentially enabling a breakthrough strategy in therapy of glioma using BMZ and other chemotherapy drugs.
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