Chlorinated paraffins: A review of sample preparation, instrumental analysis, and occurrence and distribution in food samples

Chlorinated paraffins (CPs) are released into natural environment during processes of production and utilization with diet being the most important exposure route of CPs for human beings. Short-chain chlorinated paraffins (SCCPs) have lower molecular weights, higher vapor pressures, and higher water solubilities than medium-chain chlorinated paraffins (MCCPs) and long-chain chlorinated paraffins (LCCPs), making SCCPs more likely to be readily released into the environment. Thus, SCCPs were enlisted as persistent organic pollutants being included in the Stockholm Convention in 2017. This review article summarized sample preparation and instrumental analysis methods of CPs for food types such as oil, meat, and aquatic foods. In addition, reported concentrations and profiles, dietary intake and risk assessment of CPs in food samples from various regions, such as China, Japan, and Germany are discussed for studies published between 2005 and 2022. This review is timely given the lack of a recent literature summary of the concentration and distribution of CPs in food. All these studies warranted the necessity to maintain continuous monitoring of CPs concentrations and their potential health risks given the concentrations of CPs in food are increasing worldwide.