多囊卵巢
月经周期
雄激素
雄烯二酮
内分泌学
内科学
睾酮(贴片)
医学
雄激素过量
生理学
激素
糖尿病
胰岛素抵抗
作者
Congcong Ma Data analysis,Huiyu Xu,Xianhua Zhang,Guoshuang Feng Data analysis,Li Shi,Yuan Su,Yang Li,Rongsheng Zhao,Jie Qiao
标识
DOI:10.1016/j.cca.2023.117440
摘要
The etiology of polycystic ovary syndrome (PCOS) is unclear. This study aimed to evaluate the role of classic and 11-oxygenated (11oxyC19) androgens in two typical signs of PCOS, polycystic ovary morphology (PCOM) and menstrual cycle prolongation. A total of 462 infertile women with diagnosed PCOS and/or commonly accompanied metabolic disorders were recruited. Classic and 11oxyC19 androgens were determined with a sensitive high-performance liquid chromatography-differential mobility spectrometry tandem mass spectrometry apparatus. Least absolute shrinkage and selection operator logistic regression with fivefold cross-validation was applied to construct prediction models. For PCOM, the most significant contributing androgen was testosterone (T), with the weight of 51.6%. The AUC of the prediction model was 0.824 in validation set. For menstrual cycle prolongation, androstenedione (A4) was the most significant contributing androgen with weights of 77.5%. The AUC the prediction model was less than 0.75. When including other variables, the most significant variable turned to be AMH both in PCOM and in menstrual cycle prolongation. Androgens had more contribution in PCOM than in menstrual cycle prolongation. The classic androgen T or A4 contributed more than 11oxyC19 androgens. However, their contributions were diminished when other factors were considered, especially AMH.
科研通智能强力驱动
Strongly Powered by AbleSci AI