Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer’s disease

The review focuses on three principal concepts. First, the indispensable role of Ca²⁺ homeostasis in neuronal function and its disruption in AD. Second, the interaction between Ca²⁺ signaling dysfunction and established AD hypotheses posited that Ca²⁺ dysregulation is a unifying pathway. Third, the dual role of Ca²⁺ in neurodegeneration and neuroprotection, highlighting the nuanced effects of Ca²⁺ levels on AD pathology.