Biomimetic Janus Particles Induced In Situ Interfacial Remineralization for Dentin Hypersensitivity

Abstract Dentin hypersensitivity (DH), caused by the exposure of dentin tubules, is a common complaint of dental patients. Although occlusion of the exposed tubules is the primary treatment approach, the complex oral environment, and multiple simultaneous requirements often hinder its implementation. In this study, strawberry‐shaped hemispheric Janus particles (JPs) are synthesized, and their use in the treatment of DH is evaluated in vitro and in an animal model. The hemispheric side of the JPs is modified with polymers of quaternary ammonium salts (QASs) to form a superhydrophobic coating with antibiofilm properties, while the flat side is modified with catechol groups able to form strong bonds with dentin. Even after 1 h of ultrasonication or 1000 rounds of thermal cycling, the dentin tubules are completely occluded by the JPs. Moreover, biofilm formation is not observed, and the area of living bacteria is less than 1% compared to the blank control and sodium fluoride (NaF)‐treated groups. In a rat model, the dentin tubules in the fixed specimens are completely occluded at day 3, much earlier than the occlusion obtained with commonly used NaF. These results demonstrate that JPs can provide a novel approach to the treatment of DH.