止血
纳米孔
材料科学
毛细管作用
微球
纳米纤维素
纳米技术
血栓
化学工程
纤维素
复合材料
外科
医学
工程类
作者
Zhan Xu,Wenwen Tian,Chaojun Wen,Ji X,Huailing Diao,Yuzhen Hou,Jialiang Fan,Zongxi Liu,Tianjiao Ji,Feifei Sun,Decheng Wu,Jun Zhang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-08-01
卷期号:22 (15): 6350-6358
被引量:17
标识
DOI:10.1021/acs.nanolett.2c02144
摘要
First-aid hemostatic agents for acute bleeding can save lives in emergency situations. However, rapid hemostasis remains challenging when uncontrolled hemorrhage occurs on lethal noncompressible and irregular wounds. Herein, cellulose-based cryogel microspheres with deliberately customized micromorphologies for ultrafast water transportation and diffusion, including the shark skin riblet-inspired wrinkled surface with low fluid drag and the hydrophilic nanoporous 3D networks, are developed to deal with the acute noncompressible bleeding within seconds. These cryogel microspheres can rapidly absorb a large amount of blood over 6 times their own weight in 10 s and form a robust barrier to seal a bleeding wound without applying pressure. Remarkably, massive bleeding from a cardiac penetrating hole is effectively stopped using the microspheres within 20 s and no blood leakage is observed after 30 min. Additionally, these microspheres could be readily removed without rebleeding and capillary thrombus, which is highly favorable to rapid hemostasis in emergency rescue.
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