A Novel Glucomannan from Dendrobium officinale Inhibits Obesity and Improves Insulin Sensitivity through Regulating Adipogenesis and Lipid Metabolism

-(1→ residues. Animal studies revealed that DOP-1 prevents high-fat diet (HFD)-induced obesity by mitigating weight gain, reducing inflammation, improving glucose and lipid metabolism, and alleviating insulin resistance (IR). Additionally, DOP-1 inhibited 3T3-L1 preadipocyte differentiation and lipid accumulation. Concurrently, DOP-1 enhanced lipolysis, fatty acid oxidation, and browning, ultimately enhancing insulin sensitivity in mature adipocytes. Furthermore, DOP-1 showed similar effects in HFD-fed mice. These findings suggest that DOP-1 holds potential as a functional food for obesity prevention and treatment.