Adult-Onset Still’s Disease in Pregnancy Treated by Anti-TNF Drugs: Case Report and Literature Review

Adult onset Still's illness is a non-hereditary auto inflammatory disease that affects a small number of people. From fever with arthralgia and maculopapular eruption to life-threatening symptoms such as secondary lymphohistiocytosis are all possible clinical signs. The causes of AOSD are unknown; however it appears to be linked to NK cell malfunction and the release of pro-inflammatory cytokines such as IL-1ß, IL-6, and IL-18 [1]. AOSD has been reported to occur during pregnancy, particularly in the first and second trimesters, and there is still discussion about whether it can affect the pregnancy result. We report a case of 29 years old women with Still's disease on anti TNF alpha and the follow-up during her pregnancy.