Postoperative Concurrent Radiotherapy and Chemotherapy for Malignant Cerebral Glioma

Objective To retrospectively analyze and evaluate the outcome of malignant cerebral glioma treated by chemotherapy plus radiotherapy.Methods A total of 126 patients with malignant cerebral glioma were retrospectively studied.Sixty-four patients in the radiotherapy group were irradiated with DT54-60 Gy,62 patients in the chemotherapy plus radiotherapy group were given chemotherapy(VM-26 and Me-CCNU)after exposure to DT 20 Gy.The 1-,3-and 5-year survival rates of these patients were compared.Results The 1-,3-,and 5-year survival rates of the radiotherapy group were 64.06%,31.25%,and 15.63% respectively,while the 1-,3-,and 5-year survival rates of the chemotherapy plus radiotherapy group were 80.65%,50%,and 30.65 % respectively(P 0.05).Conclusion Combination of chemotherapy and radiotherapy is effective and well-tolerated in the treatment of malignant cerebral glioma.