空肠
灌注
化学
利血平
维拉帕米
内科学
色谱法
生物化学
医学
钙
有机化学
作者
Tingting Wang,Wei Li,Yawei Yuan,Liping Wang,Xinchun Wang
出处
期刊:China journal of Chinese materia medica
[China Journal of Chinese Materia Medica]
日期:2013-04-01
被引量:1
标识
DOI:10.4268/cjcmm20130731
摘要
To study the intestinal absorption mechanism of tilianin in rats.The single-pass perfusion model was established in rats. The concentrations of tilianin with in situ intestinal perfusion were determined by HPLC. The impact factors, such as verapamil, reserpine, phloridzin and rifampicin, on Ka and Papp of tilianin in rat jejunum were investigated.Compared with the control group, Ka and Papp in rat jejunum were significantly higher after being added with verapamil and reserpine (P < 0.05). Papp of tilianin in rat jejunum was significantly lower after being added with phloridzin (P < 0.05). Compared with the control group, both Ka and Papp of tilianin in rat jejunum were not significantly higher after being added with rifampicin.Tilianin is the substrate of P-gp, BCRP and SGLT1. The effluent effect of P-gp and BCRP is the main mechanism of tilianin in intestinal absorption, indicating that tilianin can realize intestinal absorption and transport by relying on SGLT1. Tilianin is not the substrate of bile salt transporter protein.
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