Pharmacokinetic study of diclofenac sodium sustained release micropellets in rabbit

OBJECTIVE To determine pharmacokinetic and relative bioavailability of diclofence sodium sustained release micropellets(DS?SRMP) in vivo.METHODS UV method was established for assaying serum diclofence sodium concentrations in rabbits. To study theabsorptive kinetics and bioavailability of DS?SRMP. RESULTS The absorption rate of DS?SRMP in vivo was found to conform apparent zero orderkinetics(Ka 0= 12.14% /h)during the first 8 h .CONCLUSIONS The studies of pharmacokinetics in vivo indicated DS SRMP had sustained release effect.The drug concentration in blood was steady after oral administration, it could last longer and reduce the times of adminstration. The preparation release stability, bioavailability and safty.