Dietary Succinoglycan Riclin Improves Glycemia Control in Mice with Type 2 Diabetes

Riclin is a typical succinoglycan produced by an agrobacterium isolate. Our previous investigation has revealed that oral riclin restores the islet function in type 1 diabetic mice. However, whether dietary riclin improves glycemic control in type 2 diabetes (T2D) is unknown. Here, we found that dietary riclin (20 and 40 mg/kg) for 4 weeks significantly decreased fasting blood glucose (55 and 67%), improved insulin sensitivity, and decreased insulin resistance in high-fat-diet/streptozocin (HFD/STZ)-induced T2D. Riclin reduced the proportion of T helper 1 cell subsets in diabetic mice, alleviated pancreatic inflammation, and protected islet function. Moreover, dietary riclin enriched the diversity of gut microflora and restored the relative abundance of several bacterial genera in diabetes, including the strains of Clostridium, Parasutterella, Klebsiella, and Bacteroides. In db/db diabetic mice, riclin also improves glycemia control as observed in HFD/STZ-induced T2D mice. These data suggest that riclin has potential to be a functional food to treat T2D.