益生元
后代
肠道菌群
免疫系统
妊娠期
怀孕
生物
食物过敏
过敏
免疫学
菊粉
免疫耐受
失调
免疫
生理学
食品科学
遗传学
作者
Amandine Selle,Carole Brosseau,Wieneke Dijk,Angéline Duval,Grégory Bouchaud,Anaïs Rousseaux,Aurélia Bruneau,Claire Cherbuy,Mahendra Mariadassou,Véronique Cariou,S. Barbarot,Marie Bodinier
标识
DOI:10.3389/fimmu.2021.745535
摘要
Food allergy is associated with alterations in the gut microbiota, epithelial barrier, and immune tolerance. These dysfunctions are observed within the first months of life, indicating that early intervention is crucial for disease prevention. Preventive nutritional strategies with prebiotics are an attractive option, as prebiotics such as galacto-oligosaccharides and inulin can promote tolerance, epithelial barrier reinforcement, and gut microbiota modulation. Nonetheless, the ideal period for intervention remains unknown. Here, we investigated whether galacto-oligosaccharide/inulin supplementation during gestation could protect offspring from wheat allergy development in BALB/cJRj mice. We demonstrated that gestational prebiotic supplementation promoted the presence of beneficial strains in the fecal microbiota of dams during gestation and partially during mid-lactation. This specific microbiota was transferred to their offspring and maintained to adulthood. The presence of B and T regulatory immune cell subsets was also increased in the lymph nodes of offspring born from supplemented mothers, suggestive of a more tolerogenic immune environment. Indeed, antenatal prebiotic supplementation reduced the development of wheat allergy symptoms in offspring. Our study thus demonstrates that prebiotic supplementation during pregnancy induces, in the offspring, a tolerogenic environment and a microbial imprint that mitigates food allergy development.
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