Cobalt-catalyzed C-H annulation of N-aroylpicolinamides with alkynes for (NH)-isoquinolones synthesis

A cobalt-catalyzed C-H annulation of N-aroylpicolinamides with alkynes has been developed for the construction of (NH)-isoquinolone scaffolds. The reaction employs picolinamide as a traceless directing group and provides a facile and straightforward approach to access various (NH)-isoquinolone derivatives in good yields.