清脆的
癌症干细胞
生物
癌变
癌症
Cas9
转移
基因组编辑
癌症研究
计算生物学
干细胞
生物信息学
遗传学
基因
作者
Bei Wang,Alan S.L. Wong
出处
期刊:Essays in Biochemistry
[Portland Press]
日期:2022-09-01
卷期号:66 (4): 305-318
被引量:1
摘要
Cancer stem cells (CSCs) are a subpopulation of tumor cells with self-renewal ability. Increasing evidence points to the critical roles of CSCs in tumorigenesis, metastasis, therapy resistance, and cancer relapse. As such, the elimination of CSCs improves cancer treatment outcomes. However, challenges remain due to limited understanding of the molecular mechanisms governing self-renewal and survival of CSCs. Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 screening has been increasingly used to identify genetic determinants in cancers. In this primer, we discuss the progress made and emerging opportunities of coupling advanced CRISPR screening systems with CSC models to reveal the understudied vulnerabilities of CSCs.
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