RNA干扰
基因沉默
计算生物学
表观遗传学
生物
基因
生物信息学
计算机科学
遗传学
核糖核酸
作者
Argha Mario Mallick,Archana Tripathi,Sukumar Mishra,Asmita Mukherjee,Chiranjit Dutta,Ananya Chatterjee,Rituparna Roy
标识
DOI:10.1002/asia.202200451
摘要
RNA interference (RNAi) is a primitive evolutionary mechanism developed to escape incorporation of foreign genetic material. siRNA has been instrumental in achieving the therapeutic potential of RNAi by theoretically silencing any gene of interest in a reversible and sequence-specific manner. Extrinsically administered siRNA generally needs a delivery vehicle to span across different physiological barriers and load into the RISC complex in the cytoplasm in its functional form to show its efficacy. This review discusses the designing principles and examples of different classes of delivery vehicles that have proved to be efficient in RNAi therapeutics. We also briefly discuss the role of RNAi therapeutics in genetic and rare diseases, epigenetic modifications, immunomodulation and combination modality to inch closer in creating a personalized therapy for metastatic cancer. At the end, we present, strategies and look into the opportunities to develop efficient delivery vehicles for RNAi which can be translated into clinics.
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