Protective and curative activity of celery seeds on oxidative liver damage induced by cisplatin in male albino rats

This study was carried out to investigate the effect of celery seeds powder on oxidative damage of liver induced by cisplatin in male albino rats. The biological experimental was designed using forty two rats divided into seven main groups including both curative and protective groups (six rats of each) .Curative groups: Group (1) Negative control group was fed on basal diet. Group (2) Positive control group was fed on basal diet and injected with Cisplatin (5mg/kg body wt.) from the first day to induce hepatotoxicity. Group (3) and (4) were injected with Cisplatin and fed on diet containing 5% and 10% celery seeds respectively. Protective groups: Group (5) Positive control group was fed on basal diet and injected with Cisplatin (5mg/kg body wt.) after 28 days. Group (6) and (7) were fed on diet containing 5% and 10% celery seeds powder and injected with Cisplatin (5mg/kg body wt.) after 28 days. At the end of the experimental period rats were fasted overnight and sacrificed; blood samples were collected from the aorta to determine biochemical parameters. Besides, nutritional and biological parameters were recorded. The results showed that the chemical composition of celery seeds indicates the presence of high amounts of protein, lipids, crude fiber, ash and total carbohydrates, and also low moisture content, respectively. At the end of the biological experimental the results showed that celery seeds powder at 5% and 10% intake in curative and protective groups improved feed intake, the body weight gain , feed efficiency ratio, liver function, serum lipid levels and antioxidant enzymes compared with positive control groups (injected with cisplatin).It can be concluded that celery seed was fortified in the basal diet at 5 and 10%, improved the activities of liver functions, lipid profile and also improvement of antioxidant enzymes against cisplatin.