(Bromomethyl)chlorodimethylsilane

[16532-02-8] C3H8BrClSi (MW 187.54) (allylic,2 propargylic,3 and homoallylic4 bromomethylsilyl ethers are used for regio- and stereoselective introduction of hydroxymethyl2-4 or methyl2c,d groups through radical cyclization; derivatizing agent for electron capture GC5) Physical Data: bp 133–135 °C; bp 130 °C/740 mmHg; d420 1.386; nD20 1.466. Solubility: sol most organic solvents including benzene, THF, methylene chloride, chloroform, and pyridine. Form Supplied in: commercially available colorless liquid with 98% (GC) purity. Analysis of Reagent Purity: GC analysis appears best; the following spectroscopic information may also be used: FTIR (vapor phase at 225 °C): 2978 (w), 1392 (w), 1264 (m), 822 (s) cm−1;6 1H NMR (CDCl3) δ 0.58 (s, 6H), 2.65 (s, 2H); 13C NMR (CDCl3) δ 0.27, 16.47. Handling, Storage, and Precautions: moisture-sensitive; toxicological properties have not been thoroughly investigated; symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.7 Use in a fume hood.