Relationship between mild to moderate renal dysfunction and obstructive sleep apnea: Data from the European sleep apnea database

The relationship between severity of obstructive sleep apnea (OSA) and kidney function was investigated in the European Sleep Apnea Database (ESADA), where clinical, sleep, and biochemical data of patients studied for suspected OSA in 24 sleep centres of 17 European countries are stored. After excluding patients with missing data or extremely high/low creatinine values, data from 8112 subjects (2328 female) with creatinine values ranging between 0.5 and 2.0 mg% were analyzed. Estimated glomerular filtration rate (eGFR) was obtained with the Modified Diet in Renal Disease (MDRD) equation. Patients were subdivided into two groups: group 1 (n = 3709) studied by full polysomnography; group 2 (n = 4403) studied by nocturnal cardiorespiratory monitoring. Altogether, 8.5% subjects had an eGFR The ESADA study is supported by ResMed and Philips Respironics.