兄弟姐妹
萧条(经济学)
双胞胎研究
抑郁症状
发展心理学
心理学
人口学
多元统计
年轻人
临床心理学
精神科
遗传力
认知
生物
遗传学
宏观经济学
社会学
统计
经济
数学
作者
Jennifer Y. F. Lau,Thalia C. Eley
标识
DOI:10.1192/bjp.bp.105.018721
摘要
Background Depression rises markedly in adolescence, a time when increased and new genetic influences have been reported. Aims To examine ‘new’ and ‘stable’ genetic and environmental factors on depressive symptoms in adolescence and young adulthood. Method A questionnaire survey investigated a sample of twin and sibling pairs at three time points over an approximately 3-year period. Over 1800 twin and sibling pairs reported depressive symptoms at the three time points. Data were analysed using multivariate genetic models. Results Depressive symptoms at all time points were moderately heritable with substantial non-shared environmental contributions. Wave I genetic factors accounted for continuity of symptoms at waves 2 and 3. ‘New’ genetic effects at wave 2 also influenced wave 3 symptoms. New non-shared environmental influences emerged at each time point. Conclusions New genetic and environmental influences may explain age-related increases in depression across development.
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