脚手架
组织工程
材料科学
仿生学
纳米技术
骨组织
干细胞
仿生材料
生物医学工程
再生(生物学)
细胞生物学
工程类
生物
作者
Hwan D. Kim,Sivashanmugam Amirthalingam,Seunghyun L. Kim,Seunghun S. Lee,Jayakumar Rangasamy,Nathaniel S. Hwang
标识
DOI:10.1002/adhm.201700612
摘要
Abstract Various strategies have been explored to overcome critically sized bone defects via bone tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds may provide a novel platform for phenotypically stable tissue formation and stem cell differentiation. In recent years, osteoinductive and inorganic biomimetic scaffold materials have been optimized to offer an osteo‐friendly microenvironment for the osteogenic commitment of stem cells. Furthermore, scaffold structures with a microarchitecture design similar to native bone tissue are necessary for successful bone tissue regeneration. For this reason, various methods for fabricating 3D porous structures have been developed. Innovative techniques, such as 3D printing methods, are currently being utilized for optimal host stem cell infiltration, vascularization, nutrient transfer, and stem cell differentiation. In this progress report, biomimetic materials and fabrication approaches that are currently being utilized for biomimetic scaffold design are reviewed.
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