Enantioselective direct α-alkylation of cyclic ketones by means of photo-organocatalysis

We report here the first asymmetric catalytic alkylation of unmodified ketones with alkyl halides. This metal-free approach, which requires light in order to proceed, provides a rare example of highly enantioselective photochemical catalytic processes. An easily available cinchona-based primary amine catalyst guides both the stereoselectivity-defining event and, through the transient formation of photon-absorbing chiral electron donor-acceptor complexes, the photo-activation of the substrates. This journal is © the Partner Organisations 2014.