微分脉冲伏安法
材料科学
检出限
纳米线
抗坏血酸
选择性
石墨烯
纳米技术
电极
尿酸
电化学
循环伏安法
化学
色谱法
物理化学
催化作用
有机化学
生物化学
食品科学
作者
Hongyan Yue,Shuo Huang,Jian Chang,Chaejeong Heo,Fei Yao,Subash Adhikari,Fethullah Güneş,Lichun Liu,Tae Hoon Lee,Eung Seok Oh,Bing Li,Jianjiao Zhang,Ta Quang Huy,Nguyen Van Luan,Young Hee Lee
出处
期刊:ACS Nano
[American Chemical Society]
日期:2014-01-13
卷期号:8 (2): 1639-1646
被引量:279
摘要
We report that vertically aligned ZnO nanowire arrays (ZnO NWAs) were fabricated on 3D graphene foam (GF) and used to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA) by a differential pulse voltammetry method. The optimized ZnO NWA/GF electrode provided a high surface area and high selectivity with a detection limit of 1 nM for UA and DA. The high selectivity in the oxidation potential was explained by the gap difference between the lowest unoccupied and highest occupied molecular orbitals of a biomolecule for a set of given electrodes. This method was further used to detect UA levels in the serum of patients with Parkinson’s disease (PD). The UA level was 25% lower in PD patients than in healthy individuals. This finding strongly implies that UA can be used as a biomarker for PD.
科研通智能强力驱动
Strongly Powered by AbleSci AI