内化
材料科学
聚苯乙烯
杰纳斯
纳米复合材料
双模
叶酸受体
药物输送
叶酸
纳米技术
细胞
癌细胞
生物化学
聚合物
化学
癌症
医学
复合材料
内科学
航空航天工程
工程类
作者
Rui Wang,Giovanni M. Pauletti,Juntao Wang,Jiaming Zhang,Rodney C. Ewing,Yilong Wang,Donglu Shi
标识
DOI:10.1002/adma.201301376
摘要
Folic acid (FA) and doxorubicin (DOX) are coupled separately onto Fe3O4@SiO2 and polystyrene surfaces of a unique polystyrene/Fe3O4@SiO2 Janus structure. This super-paramagnetic, dual-functionalized Janus nanocomposite enables effective tumor cell targeting and internalization via the folate receptor, and induces significant cancer cell death by controlled, stimulus-induced drug release under acidic conditions in endosomal compartments. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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