医学
鼠李糖乳杆菌
嗜酸性粒细胞
白细胞
安慰剂
免疫球蛋白E
内科学
免疫学
随机对照试验
嗜酸性阳离子蛋白
胃肠病学
抗体
益生菌
哮喘
遗传学
替代医学
病理
细菌
生物
作者
Rong‐Hwa Jan,Chia‐Jung Chen,Li‐Kuang Chen,Shu‐Hui Wen,Teng-Yi Lin
标识
DOI:10.1016/j.tcmj.2011.05.003
摘要
Probiotics have previously been shown to reduce the severity of atopic disease in infants and children. However, the immunological changes induced by this treatment that might account for the clinical improvement are still unclear. In this study, we examined the effect of Lactobacillus rhamnosus on the clinical symptoms and medication use among children with established allergic rhinitis. We also investigated the effect of probiotics on the white blood cell counts, red blood cell counts, platelet counts, eosinophil counts, and IgE antibody levels. Atopic children with current rhinitis received 4 × 109 colony forming units/g of L rhamnosus (n = 98) or a placebo (n = 100). Both were given this daily as a powder mixed with food or water. The SCORing Allergic rhinitis index (specific symptoms scores and symptom medication scores), which measures of the extent and severity of allergic rhinitis, was assessed for each patient at the five visits. These five scheduled visits were at 2 weeks before starting the treatment (Visit 0), at the beginning of the treatment (Visit 1), then 4 weeks (Visit 2), 8 weeks (Visit 3), and 12 weeks (Visit 4) after starting the treatment. The white blood cell, red blood cell, platelet, and eosinophil counts as well as the IgE antibody levels of the individuals were evaluated before and after 3 months of treatment. The major outcome, indicating the efficacy of L rhamnosus treatment, was no reduction in rhinitis symptoms or drug scores. No significant statistical differences were found between baseline and 3 months for the probiotic and placebo groups when any immunological and blood cell variable was examined. Our data demonstrates that L rhamnosus treatment neither reduced rhinitis symptom scores nor altered immunological parameters in symptomatic children.
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