Abstract Summary: DomCut is a program to predict inter-domain linker regions solely by amino acid sequence information. The prediction is made by using linker index deduced from a data set of domain/linker segments. The linker preference profile, which is the averaged linker index along a sequence, can be visualized in the graphical interface. Availability: The web server, together with supplementary information, is available at http://www.kazusa.or.jp/tech/suyama/domcut. The distribution version of DomCut is also available upon request from the authors. Contact: suyama@embl-heidelberg.de * To whom correspondence should be addressed. † Present address: Biocomputing, EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany.