化学
生物分子
糖蛋白
酰胺
计算生物学
生物物理学
生物化学
生物
标识
DOI:10.1016/0924-2031(93)87065-2
摘要
This review article discusses the amide modes associated with the reverse turns in peptides and proteins. Applications of the normal mode analysis treatment to different types of β-turns in peptides and in proteins like insulin, metallothioneins, phosvitin, and glycoproteins are presented. Similar analysis is carried out on γ-turns in peptides and proteins. The article attempts to bring to notice the so far neglected reverse turn, namely, cross-β conformation. Possible models for further physicochemical studies of this conformation are presented. Applications of cross-β conformation to insulin fibrils, bacteriophage T4, prebiotic polypeptides, DNA—protein interactions, and the Alzheimer's disease are presented and discussed. This article concludes with a critical assessment, a discussion of power and limitations of vibrational spectroscopy in study protein conformation, and a discussion on perspectives for the future.
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