Transfection of SSTR-1 and SSTR-2 Inhibits Panc-1 Cell Proliferation and Renders Panc-1 Cells Responsive to Somatostatin Analogue

These findings suggest, for the first time, a synergistic inhibitory effect of multiple SSTRs in response to a somatostatin analogue in Panc-1 cells. These studies may improve our understanding of the mechanism by which SSTR inhibits cell growth and lead to novel gene therapies for pancreatic cancer.