FDG PET/CT Imaging of NUT Midline Carcinoma

NUT midline carcinoma is a very rare, poorly differentiated, highly aggressive cancer originating from midline body locations, most often in adolescents or young adults. Advanced local disease and distant hematogenous metastases are typical. NMC is genetically defined by chromosomal rearrangements of the NUT gene on chromosome 15q14 forming a BRD4-NUT fusion oncogene which blocks epithelial differentiation, resulting in uncontrolled cell growth. Use of FDG PET/CT for imaging of NMC has not been previously reported. This case demonstrates that FDG PET can assess NMC disease extent and may be useful in assessing response to chemotherapy.