自噬
巨噬细胞
脂质代谢
炎症
细胞生物学
泡沫电池
生物
氧化应激
平衡
免疫学
内分泌学
生物化学
细胞凋亡
体外
作者
Ismail Sergin,Babak Razani
标识
DOI:10.1016/j.tem.2014.03.010
摘要
Autophagy (or 'self-eating') is the process by which cellular contents are recycled to support downstream metabolism. An explosion in research in the past decade has implicated its role in both health and disease and established the importance of the autophagic response during periods of stress and nutrient deprivation. Atherosclerosis is a state where chronic exposure to cellular stressors promotes disease progression, and alterations in autophagy are predicted to be consequential. Recent reports linking macrophage autophagy to lipid metabolism, blunted inflammatory signaling, and an overall suppression of proatherogenic processes support this notion. We review these data and provide a framework for understanding the role of macrophage autophagy in the pathogenesis of atherosclerosis, one of the most formidable diseases of our time.
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