Photoimmunology: how ultraviolet radiation affects the immune system

Ultraviolet (UV) radiation is a ubiquitous component of the environment that has important effects on a wide range of cell functions. Short-wavelength UVB radiation induces sunburn and is a potent immunomodulator, yet longer-wavelength, lower-energy UVA radiation also has effects on mammalian immunity. This Review discusses current knowledge regarding the mechanisms by which UV radiation can modify innate and adaptive immune responses and how this immunomodulatory capacity can be both beneficial in the case of inflammatory and autoimmune diseases, and detrimental in the case of skin cancer and the response to several infectious agents. Ultraviolet radiation (UVR) modulates innate and adaptive immune responses at both local and systemic levels; understanding the mechanisms of this immunomodulatory capacity can explain how UVR has both beneficial and detrimental effects.