免疫系统
紫外线辐射
免疫学
晒伤
免疫
辐射
生物
先天免疫系统
癌症研究
化学
获得性免疫系统
医学
物理
皮肤病科
光学
放射化学
作者
Jamie J. Bernard,Richard L. Gallo,Jean Krutmann
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2019-06-18
卷期号:19 (11): 688-701
被引量:162
标识
DOI:10.1038/s41577-019-0185-9
摘要
Ultraviolet (UV) radiation is a ubiquitous component of the environment that has important effects on a wide range of cell functions. Short-wavelength UVB radiation induces sunburn and is a potent immunomodulator, yet longer-wavelength, lower-energy UVA radiation also has effects on mammalian immunity. This Review discusses current knowledge regarding the mechanisms by which UV radiation can modify innate and adaptive immune responses and how this immunomodulatory capacity can be both beneficial in the case of inflammatory and autoimmune diseases, and detrimental in the case of skin cancer and the response to several infectious agents.
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