丁螺环酮
神经认知
哈姆德
阳性与阴性症状量表
汉密尔顿焦虑量表
精神科
心理学
精神分裂症(面向对象编程)
韦氏成人智力量表
随机对照试验
临床全球印象
评定量表
临床心理学
焦虑
医学
内科学
认知
精神病
安慰剂
发展心理学
替代医学
受体
兴奋剂
病理
作者
Yu Wang,Xiao Yang,Xiuli Song,Liansheng Zhao,Jinxue Wei,Jixiang Wang,Hong Tian,Congyu Zheng,Min Wei,Qiang Wang,Wanjun Guo,Wei Deng,Tao Li,Xiaoyan Ma
标识
DOI:10.1016/j.schres.2019.05.006
摘要
We conducted a 24-week, randomized, double-blind parallel-controlled trial to test whether buspirone is beneficial to improve cognitive deficits of schizophrenia because it remains unclear. Two hundred patients received in random order either co-treatment buspirone with AAPDs or monotherapy with AAPDs. All patients had been treated with a stable dosage of AAPDs for at least three months. The positive and negative syndrome scale (PANSS), Hamilton Depression Scale-24 (HAMD-24), and 14-item Hamilton Rating Scale for Anxiety (HAMA-14) were used to evaluate clinical symptoms. The short version of Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC) was used to assess neurocognitive function. Social function and family burden were evaluated by Social Disability Screening Schedule (SDSS) and Family Burden Interview Schedule (FBIS). All patients were enrolled at baseline and followed up after 12 and 24 weeks. A total of 196 patients completed the trial, with 99 in the combined treatment group and 97 in the control group. During the intervention, the score of PANSS, HAMD-24, and HAMA-14 decreased slightly without group differences. Repeated measures ANOVA showed significant differences between the two groups in the score of arithmetic, similarities, picture completion, block design, SDSS, and FBIS (P < 0.05), but no difference was found with regard to the score of information, digital span test, or digital symbols (P > 0.05). In conclusion, co-treatment with buspirone and APPDs outperformed APPDs alone in improving cognitive deficit and reducing family burden of schizophrenia. Buspirone may be a promising candidate for co-treatment of schizophrenia-associated cognitive deficits.
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