肺动脉高压
医学
慢性血栓栓塞性肺高压
重症监护医学
胚胎血管重塑
肺血管系统
转化研究
肺病理学
疾病
心理干预
临床实习
病理
心脏病学
肺
内科学
物理疗法
精神科
作者
Marc Humbert,Christophe Guignabert,Sébastien Bonnet,Peter Dorfmüller,James R. Klinger,Mark R. Nicolls,Andrea Olschewski,Soni Savai Pullamsetti,Ralph Theo Schermuly,Kurt R. Stenmark,Marlene Rabinovitch
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:2019-01-01
卷期号:53 (1): 1801887-1801887
被引量:788
标识
DOI:10.1183/13993003.01887-2018
摘要
Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (e.g. chronic thromboembolic PH and pulmonary veno-occlusive disease). However, PH remains an incurable condition with a high mortality rate, underscoring the need for a better transfer of novel scientific knowledge into healthcare interventions. Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post-capillary involvement of pulmonary vessels) and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of PH. We also discuss ways to improve management and to support and optimise drug development in this research field.
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