Cancer Immunotherapy: Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide‐Embedded Large‐Pore Mesoporous Organosilica Core–Shell Nanospheres (Adv. Healthcare Mater. 9/2019)

In article number 1900039, Yongbin Mou, Zhaogang Teng, and co-workers show that iron oxide-embedded large-pore mesoporous organosilica nanospheres (IO-LPMONs) with core-shell structure, high surface area, large mesopores and huge pore volume can initiate DC-based T cell activation and tumor-associated macrophage (TAM) polarization simultaneously. The combined T cell activation and macrophage polarization strategy based on the IO-LPMONs elicits remarkable combined antitumor effects. This study demonstrates that the new-synthesized IO-LPMONs hold excellent potential as an immune modulator for cancer immunotherapy.