Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases

低聚物 蛋白质折叠 疾病 计算生物学 神经退行性变 蛋白质聚集 机制(生物学) 药物发现 混乱 神经科学 化学 医学 生物 淀粉样蛋白(真菌学) 生物信息学 生物化学 病理 心理学 哲学 有机化学 认识论 精神分析
作者
Klara Kulenkampff,Adriana-M. Wolf Perez,Pietro Sormanni,Johnny Habchi,Michele Vendruscolo
出处
期刊:Nature Reviews Chemistry [Nature Portfolio]
卷期号:5 (4): 277-294 被引量:80
标识
DOI:10.1038/s41570-021-00254-9
摘要

Protein misfolding and aggregation are characteristic of a wide range of neurodegenerative disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the aggregation of otherwise soluble and functional proteins into amyloid aggregates. Although for many decades such amyloid deposits have been thought to be responsible for disease progression, it is now increasingly recognized that the misfolded protein oligomers formed during aggregation are, instead, the main agents causing pathological processes. These oligomers are transient and heterogeneous, which makes it difficult to detect and quantify them, generating confusion about their exact role in disease. The lack of suitable methods to address these challenges has hampered efforts to investigate the molecular mechanisms of oligomer toxicity and to develop oligomer-based diagnostic and therapeutic tools to combat protein misfolding diseases. In this Review, we describe methods to quantify misfolded protein oligomers, with particular emphasis on diagnostic applications as disease biomarkers and on therapeutic applications as target biomarkers. The development of these methods is ongoing, and we discuss the challenges that remain to be addressed to establish measurement tools capable of overcoming existing limitations and to meet present needs. Alzheimer and Parkinson diseases involve protein oligomers that are dilute, transient and heterogeneous. This Review describes techniques to characterize these challenging analytes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
sc发布了新的文献求助10
刚刚
科研小民工应助mimilv采纳,获得200
刚刚
NexusExplorer应助锅巴采纳,获得10
刚刚
杨冰发布了新的文献求助10
1秒前
柴柴完成签到,获得积分10
2秒前
陶世立完成签到 ,获得积分10
2秒前
ddffgz发布了新的文献求助10
2秒前
JJM发布了新的文献求助10
2秒前
cxjie320完成签到,获得积分10
2秒前
3秒前
3秒前
5秒前
MaYue完成签到,获得积分10
5秒前
5秒前
小橙子完成签到,获得积分10
5秒前
Rheanna完成签到,获得积分10
6秒前
6秒前
孤独听雨的猫完成签到 ,获得积分10
6秒前
海阔天空发布了新的文献求助10
6秒前
戴岱发布了新的文献求助10
7秒前
7秒前
LUIOO完成签到,获得积分10
8秒前
偶然847完成签到,获得积分10
9秒前
hunter完成签到,获得积分10
10秒前
小至发布了新的文献求助10
10秒前
迷人尔蓝完成签到,获得积分20
10秒前
zxzx完成签到,获得积分10
10秒前
英姑应助荒野脱马采纳,获得10
10秒前
飘零枫叶发布了新的文献求助10
11秒前
晚晚完成签到,获得积分10
11秒前
11秒前
年轻的小唐完成签到 ,获得积分10
11秒前
彩色的荔枝完成签到,获得积分10
12秒前
cesar完成签到,获得积分10
13秒前
MrLiu完成签到,获得积分10
13秒前
theverve完成签到,获得积分10
13秒前
Linda琳完成签到,获得积分10
13秒前
14秒前
14秒前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Technologies supporting mass customization of apparel: A pilot project 450
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
Brain and Heart The Triumphs and Struggles of a Pediatric Neurosurgeon 400
Cybersecurity Blueprint – Transitioning to Tech 400
Mixing the elements of mass customisation 400
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3784938
求助须知:如何正确求助?哪些是违规求助? 3330274
关于积分的说明 10245276
捐赠科研通 3045590
什么是DOI,文献DOI怎么找? 1671719
邀请新用户注册赠送积分活动 800686
科研通“疑难数据库(出版商)”最低求助积分说明 759609