狼疮性肾炎
生发中心
免疫系统
生物
免疫学
系统性红斑狼疮
炎症
先天免疫系统
细胞生物学
B细胞
医学
抗体
疾病
病理
作者
Eleni Frangou,Spyros Georgakis,George Bertsias
标识
DOI:10.1016/j.clim.2020.108445
摘要
Recent progress has highlighted the involvement of a variety of innate and adaptive immune cells in lupus nephritis. These include activated neutrophils producing extracellular chromatin traps that induce type I interferon production and endothelial injury, metabolically-rewired IL-17–producing T-cells causing tissue inflammation, follicular and extra-follicular helper T-cells promoting the maturation of autoantibody-producing B-cells that may also sustain the formation of germinal centers, and alternatively activated monocytes/macrophages participating in tissue repair and remodeling. The role of resident cells such as podocytes and tubular epithelial cells is increasingly recognized in regulating the local immune responses and determining the kidney function and integrity. These findings are corroborated by advanced, high-throughput genomic studies, which have revealed an unprecedented amount of data highlighting the molecular heterogeneity of immune and non-immune cells implicated in lupus kidney disease. Importantly, this research has led to the discovery of putative pathogenic pathways, enabling the rationale design of novel treatments. • Activated neutrophils, Th17 and follicular helper T-cells play major role in lupus nephritis • Activated kidney resident cells due to inflammatory milieu are important in determining kidney function and integrity • Gene profiling studies have unraveled significant molecular heterogeneity of lupus nephritis and identified putative therapeutic targets
科研通智能强力驱动
Strongly Powered by AbleSci AI