Kidney injury induced by butylphthalide and sodium chloride injection

A 58-year-old male patient received aspirin enteric-coated tablets 200 mg and rosuvastatin calcium 10 mg once daily by mouth, IV infusions of butylphthalide and sodium chloride injection 100 ml (containing butylphthalide 25 mg and sodium chloride 0.9 g) twice daily and troxorutin brain protein hydrolysate 10 ml once daily for acute ischemic stroke. Seven days later, laboratory tests showed blood urea 6.9 mmol/L, serum creatinine (Scr) 131 μmol/L, and blood cystatin C 1.54 mg/L. Kidney injury induced by butylphthalide and sodium chloride injection was considered. Butylphthalide and sodium chloride injection was stopped but the other drugs as well as Xueshuantong for injection (注射用血栓通) and Corbrin capsule (百令胶囊) were given. Laboratory tests showed blood urea 6.2 mmol/L, Scr 104 μmol/L, and blood cystatin C 1.05 mg/L 6 days later and then blood urea 5.9 mmol/L, Scr 101 μmol/L, and blood cystatin C 1.00 mg 2 months later. Key words: Stroke; Acute kidney injury; Butylphthalide and sodium chloride injection