神经调节
脑深部刺激
背景(考古学)
医学
脑刺激
神经科学
萧条(经济学)
脑电刺激
随机对照试验
刺激
大脑活动与冥想
心理学
内科学
脑电图
生物
宏观经济学
古生物学
经济
疾病
帕金森病
作者
Katherine W. Scangos,Ghassan S. Makhoul,Leo P. Sugrue,Edward F. Chang,Andrew D. Krystal
出处
期刊:Nature Medicine
[Springer Nature]
日期:2021-01-18
卷期号:27 (2): 229-231
被引量:127
标识
DOI:10.1038/s41591-020-01175-8
摘要
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof of concept for personalized, circuit-specific medicine in psychiatry.
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