Intramolecular 5- endo -trig aminopalladation of β-hydroxy-γ-alkenylamine: efficient route to a pyrrolidine ring and its application for the synthesis of (−)-8,8a-di- epi -swainsonine

The intramolecular aminopalladation reaction of l -serine derived β-hydroxy-γ-alkenylamines undergoes 5- endo -trig cyclization to furnish pyrrolidine rings in high yields. The pyrrolidine thus obtained were elaborated to the synthesis of (−)-8,8a-di- epi -swainsonine.