Immune biomarkers associated with clinical benefit from atezolizumab (MPDL3280a; anti-PD-L1) in advanced urothelial bladder cancer (UBC)
作者
Thomas Powles,Dorothee Nickles,Eliezer M. Van Allen,Colombe Chappey,Wei Zou,Marcin Kowanetz,Edward E. Kadel,Mitchell Denker,Zachary Boyd,Nicholas J. Vogelzang,Joseph Kim,Joaquim Bellmunt,Yohann Loriot,Charles G. Drake,Carol O’Hear,Marcella Fassò,Priti S. Hegde,Sanjeev Mariathasan
Meeting abstracts Atezolizumab (anti-PD-L1) has demonstrated robust clinical activity in UBC [[1][1]]. Elevated PD-L1 expression on tumor-infiltrating immune cells (IC) is associated with increased clinical efficacy; however, the contribution of other immune biomarkers is unknown. In this study, we