Spectrophotometric Determination Of Secnidazole In Tablets

An extractive spectrophotometric method was established for the determination of secnidazole in pure and tablets using bromothymol blue as an analytical reagent. The method is based on the formation of a chloroform-extractable yellow colored ion-associated complex (bromothymol blue cation-secnidazole anion) through the reaction of secnidazole with an excess of bromothymol blue at pH 4.4. Beer's law was obeyed in the range of 2.0-40.0 µg/ml. The method is simple, precise and accurate for pure analyte with recovery (98.0-102.0%) and also, this does not require any separation of soluble excipients in tablets.